Linked Life Data

6762277

Source:http://linkedlifedata.com/resource/pubmed/id/6762277

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-5-27
pubmed:abstractText
Immunologic responses to insulin can be manifested by both laboratory animals immunized with insulin as a known modifiable model antigen and by patients receiving heterologous insulin as a mainstay of therapy for insulin dependent diabetes mellitus. The use of purified insulin as a model antigen for the study of cellular interactions, T cell antigen recognition, and the mechanism and specificity of Ir gene action in experimental animals has given us great insight into the potential workings of these complex functions. In humans with IDDM, immune cofactors may play a role in both the pathogenesis of disease as well as the obvious complications of therapy. Intense study of cellular, genetic, biochemical, and immunologic parameters in these patients with IDDM may provide us with unique insights into the complex regulatory interactions between the immunologic and endocrine-metabolic systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0277-9366
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-35
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Immunologic reactivity to insulin: animal models and clinical syndromes.
pubmed:publicationType
Journal Article, Comparative Study, Review