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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1983-1-19
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pubmed:abstractText |
1 Forty-one patients with primary (essential) hypertension were treated with captopril alone or in combination with hydrochlorothiazide for 12-36 months. 2 During an initial dose-titration period mean blood pressure fell from 174/111 mm Hg to 134/88 mm Hg supine and from 170/116 mm Hg to 126/93 mm Hg standing after 3 months' treatment. 3 During long-term treatment with unchanged or reduced doses of captopril or hydrochlorothiazide, or both, blood pressure remained substantially reduced. Mean supine blood pressure at 24 months was 136/90 mm Hg and at 36 months 138/90 mm Hg. 4 In 12 patients with clearly defined low renin (essential) hypertension initial blood pressure reduction was less than in patients with normal renin hypertension after 1 month's treatment (162/102 mm Hg v 143/92 mm Hg). After 24 months of treatment, however, the treatment results were similar in the two groups. 5 Except for one case of reversible proteinuria no serious side effects were seen during treatment periods of up to three years. 6 Captopril alone or in combination with hydrochlorothiazide seems to be an effective and safe drug in the long-term treatment of primary hypertension.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6753894-217289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6753894-616070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6753894-6280477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6753894-663548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6753894-6803561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6753894-7015795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6753894-7036617
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0306-5251
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133S-137S
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6753894-Adult,
pubmed-meshheading:6753894-Captopril,
pubmed-meshheading:6753894-Drug Therapy, Combination,
pubmed-meshheading:6753894-Female,
pubmed-meshheading:6753894-Humans,
pubmed-meshheading:6753894-Hydrochlorothiazide,
pubmed-meshheading:6753894-Hypertension,
pubmed-meshheading:6753894-Male,
pubmed-meshheading:6753894-Middle Aged,
pubmed-meshheading:6753894-Proline
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pubmed:year |
1982
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pubmed:articleTitle |
Long-term experience of captopril in the treatment of primary (essential) hypertension.
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pubmed:publicationType |
Journal Article
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