Linked Life Data

6744301

Source:http://linkedlifedata.com/resource/pubmed/id/6744301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1984-9-19
pubmed:abstractText
Changes occur in polyamine metabolism which are associated with differentiation of Friend erythroleukemia cells in culture. The intracellular distribution of the polyamines changes, the absolute level of each of the major polyamine falls, and the uptake and metabolism of exogenous putrescine is altered during the course of differentiation. We have examined the labeling of putrescine metabolites after the administration of radioactive putrescine, either as a single dose added at the onset of induction, or as a pulse label added at various times during the course of differentiation. In these experiments we measured both acid-soluble and acid-precipitable radioactivity. The conversion of putrescine to gamma-aminobutyric acid is enhanced in the cell induced to differentiate, and the acid-precipitable fraction rises as the percentage of total cell-associated radioactivity in the induced cell. We have identified hypusine [N-epsilon-(4-amino-2-hydroxybutyl)lysine] as a major radioactive component of a single radioactive Mr 18,000 protein band in both the noninduced and the induced cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3841-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Polyamine metabolism in differentiating Friend erythroleukemia cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't