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pubmed-article:6731955pubmed:abstractTextA plasma assay for paracetamol by HPLC is described. Paracetamol is extracted with diethyl ether in the presence of an internal standard, beta- hydroxyethyltheophylline . The extracts are analysed using reversed phase chromatography (Radial Pak C18 column), the mobile phase consisting of a buffer mixture of 0.01 mol/l acetate (pH 4)-acetonitrile (920-80, v/v). The method is simple, rapid, precise and sensitive (lower level of sensitivity 0.13 mumol/l). It was used in a pharmacokinetic study in twelve volunteers.lld:pubmed
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pubmed-article:6731955pubmed:statusMEDLINElld:pubmed
pubmed-article:6731955pubmed:issn0003-3898lld:pubmed
pubmed-article:6731955pubmed:authorpubmed-author:AlbinHHlld:pubmed
pubmed-article:6731955pubmed:authorpubmed-author:VinçonGGlld:pubmed
pubmed-article:6731955pubmed:authorpubmed-author:Demotes-Maina...lld:pubmed
pubmed-article:6731955pubmed:authorpubmed-author:JarryCClld:pubmed
pubmed-article:6731955pubmed:issnTypePrintlld:pubmed
pubmed-article:6731955pubmed:volume42lld:pubmed
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pubmed-article:6731955pubmed:pagination9-13lld:pubmed
pubmed-article:6731955pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:6731955pubmed:year1984lld:pubmed
pubmed-article:6731955pubmed:articleTitle[Plasma determination of paracetamol using high performance liquid chromatography. Application to a pharmacokinetic study].lld:pubmed
pubmed-article:6731955pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:6731955pubmed:publicationTypeEnglish Abstractlld:pubmed