Linked Life Data

6729111

Source:http://linkedlifedata.com/resource/pubmed/id/6729111

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-7-18
pubmed:abstractText
This paper describes experiments designed to investigate possible biological hazards associated with magnetic resonance (MR) imaging. Mouse C3H 10T1/2 cells were exposed to a powerful magnetic field (up to 2.7 T) for periods up to 17 hours together with pulsed field gradients and radio-frequency excitation and compared with untreated controls and cells exposed to gamma rays (0.3 to 0.4 Gy). Several biological endpoints were studied. In the case of oncogenic transformation, no significant difference could be demonstrated between controls and either the gamma-irradiated or MR-exposed cells. When mitotic cells were examined for chromosomal alterations, the frequencies of both chromosomal aberrations per cell and sister chromatid exchanges per chromosome were significantly enhanced over control levels after ionizing radiation exposures but were similar to control (or less) after MR exposures. These studies confirm the known deleterious effects of ionizing radiation (even at low doses) for chromosomal damage, if not for oncogenic transformation, yet show that MR exposures even of long duration (up to 17 hours) at high field strengths (up to 2.7 T) do not result in effects greater than 0.3 Gy of gamma rays. Negative results do not conclusively rule out a health risk; however, the data clearly mitigate against an association between exposure to MR imaging modalities and both carcinogenic and genotoxic effects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0033-8419
pubmed:author
pubmed:issnType
Print
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-202
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Magnetic resonance and ionizing radiation: a comparative evaluation in vitro of oncogenic and genotoxic potential.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.