Linked Life Data

6727029

Source:http://linkedlifedata.com/resource/pubmed/id/6727029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-7-9
pubmed:abstractText
Mitochondrial oxidative phosphorylation, calcium transport activity and calcium content were investigated in dog hearts injured by excessive noradrenaline (NA). Diffuse cardiac injury was produced by a 5-hour infusion of NA (2 or 5 micrograms/kg/min), and the injury was evaluated based on ECG and hemodynamic changes. Mitochondrial calcium uptake and binding activities measured in the presence of ATP showed no significant differences between the control and NA groups. However, the calcium content of heart mitochondria isolated from the NA groups, state 3 respiration and the respiratory control index were significantly depressed without any change in the ADP/O ratio. These results suggest that excessive NA causes the intracellular calcium overload and the depression of mitochondrial respiration, and the both of these changes may play a key role in the pathogenesis of myocardial injury through the insufficient control of cytosolic calcium levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0047-1828
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
492-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effects of excessive noradrenaline on cardiac mitochondrial calcium transport and oxidative phosphorylation.
pubmed:publicationType
Journal Article