Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-7-11
pubmed:abstractText
We examined the effects of brief current pulses on the pacemaker oscillations of the Purkinje fiber using the model of McAllister , Noble, and Tsien (1975. J. Physiol. [Lond.]. 251:1-57). This model was used to construct phase-response curves for brief electric stimuli to find "black holes," where rhythmic activity of the Purkinje fiber ceases. In our computer simulation, a brief current stimulus of the right magnitude and timing annihilated oscillations in membrane potential. The model also revealed a sequence of alternating periodic and chaotic regimes as the strength of a steady bias current is varied. We compared the results of our computer simulations with experimental work on Purkinje fibers and pointed out the importance of modeling results of this kind for understanding cardiac arrhythmias.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-1089208, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-12991237, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-262379, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-390080, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-493975, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-6273533, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-6305437, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-6309266, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-6809065, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-6857229, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-7016362, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-7041803, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-720633, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-7349933, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-7386358, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-7408126, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-7441560, http://linkedlifedata.com/resource/pubmed/commentcorrection/6722270-887919
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3495
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
841-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Impulse responses of automaticity in the Purkinje fiber.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.