Linked Life Data

6704730

Source:http://linkedlifedata.com/resource/pubmed/id/6704730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-5-24
pubmed:abstractText
To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse injection of deuterium-labeled choline into the tail vein. The S-line rats exhibited higher concentrations of labeled acetylcholine (ACh) in the cortex than the rats bred for resistance to DFP (Flinders R-line). To determine the contribution of postsynaptic cholinergic mechanisms the concentration of brain muscarinic ACh receptors (mAChR) was determined. The S-line rats exhibited higher concentrations of striatal and hippocampal mAChR than the R-line rats. Thus, both pre- and postsynaptic cholinergic mechanisms may contribute to the increased sensitivity to DFP but their relative importance varies with brain region: increased ACh synthesis in the cortex and increased concentrations of mAChR in the striatum and hippocampus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
294
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-32
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Selective breeding for differences in cholinergic function: pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't