Linked Life Data

6697567

Source:http://linkedlifedata.com/resource/pubmed/id/6697567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-3-30
pubmed:abstractText
In accordance with the clonal selection theory the authors intended to prevent the development of autoimmune hepatitis in rabbits with the aid of radiolabelled liver specific membrane (LSP) antigen administered prior to the antigen immunization. The autoimmune hepatitis was produced in rabbits by allogen LSP antigen. The inflammatory reaction was characterized by the serum glutamic oxaloacetic transaminase activity in the sera, by the parameters of immune reaction as well as by lysosomal membrane alterations in the liver and by morphological findings. The process was inhibited by pre-treatment with hot labelled LSP antigen. Neither the radioactively labelled growth hormone pre-treatment, nor the application of hot labelled antigen at the last week of the experiment were able to prevent the humoral and lysosomal, as well as the morphological data characteristic for autoimmune hepatitis. The results obtained may be understood considering the mechanism of clonal selection.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
360-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Inhibition of autoimmune hepatitis with hot labelled liver specific antigen.
pubmed:publicationType
Journal Article