The inhibitory actions of 3 putative dopamine receptor agonists on the firing of neurons in slices of rat substantia nigra in vitro was examined. The EPMR values for 3-PPP, RDS-127 and TL-99 were 1.11, 2.66 X 10(-3) and 2.4 X 10(-4) respectively. All 3 agonist effects were antagonized by 1 microM sulpiride.
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