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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1984-3-12
|
| pubmed:abstractText |
The partitioning of the acylenzyme acetyl-(Gly)n-Phe(NO2)-chymotrypsin (n = 0,1,2) to peptide and peptide acid is observed spectrophotometrically. Values of partitioning ratios for various nucleophiles are calculated from the spectral data. They are a measure for the "true" nucleophile reactivity and are useful in the prediction of the best experimental conditions in enzymic peptide synthesis. A large difference in the nucleophile reactivity is observed which is attributed to the S'2-P'2 interaction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
118
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
317-23
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6696760-Animals,
pubmed-meshheading:6696760-Cattle,
pubmed-meshheading:6696760-Chymotrypsin,
pubmed-meshheading:6696760-Indicators and Reagents,
pubmed-meshheading:6696760-Kinetics,
pubmed-meshheading:6696760-Pancreas,
pubmed-meshheading:6696760-Peptides,
pubmed-meshheading:6696760-Substrate Specificity
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Nucleophile specificity in chymotrypsin peptide synthesis.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|