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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1977-6-30
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pubmed:abstractText |
Outbred Wistar rats were immunised with a single intraperitoneal injection of a mixture of 30 mg of A1(OH)3 and 100microng of gonococcal zeolite antigen (ZA). Ten days after immunisation, ZA prepared from T1 and T4 colonies of Neisseria gonorrhoeae strain GC6 (GC6-T1 ZA and GC6-T4 ZA) were able to elicit a reaginic (IgE) response which declined to low levels by 35 days. There was a significant amount of histamine release from the mast cells of actively-sensitised rats on challenge with a specific gonococcal antigen. The antisera heated at a temperature of 56 degrees C for four hours failed to elicit a passive cutaneous anaphylaxis (PCA) reaction, indicating a lack of IgGa antibody. In addition antisera to GC6-T1 ZA gave a positive PCA reaction with GC6-T4 ZA and ZA prepared from T1 colonies of six heterologous gonococcal strains suggesting that these strains of N. gonorrhoeae share common antigenic determinants.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-14047217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-237620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-4116914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-4138181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-4139123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-4188038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-4201268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-4626516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-5411933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-812926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-823118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-939584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/66964-989469
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-134X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
106-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1977
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pubmed:articleTitle |
Homocytotropic antibodies (IgE) to Neisseria gonorrhoeae in the rat and a cross-reactivity of heterologous gonococcal strains.
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pubmed:publicationType |
Journal Article
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