Linked Life Data

6684633

Source:http://linkedlifedata.com/resource/pubmed/id/6684633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-11-23
pubmed:abstractText
This study was undertaken to investigate to what extent the cardiodepression of acute alcohol intoxication is dose-dependent and to assess the validity of isovolumetric and afterload parameters in the latter condition. Isovolumetric and ejection phase parameters were measured in-situ in the intact heart of the guinea pig. The diastolic and systolic pressure-volume-relationships were calculated on the basis of direct measurements obtained at control conditions and during acuta alcohol intoxication at blood alcohol concentrations (BAC) of 160 and 280 mg/100 ml, respectively. Cardiodepression was dose-dependent; left ventricular isovolumetric pressure fell 13% at a BAC of 280 mg/100 ml, maximal rate of pressure rise (dp/dt max) decreased 33%. The changes in afterload parameters were less consistent: there was an increase in left ventricular isovolumetric pressure and dp/dt max in the group with BAC of 160 mg/100 ml, but both of these parameters decreased at BAC levels of 280 mg/100 ml. Stroke volume and preload decreased comparably in both groups. The divergent pattern of induced hemodynamic alterations may be due to peripheral effects of ethanol and/or counter-regulatory adrenergic mechanisms. The mortality rate associated with BAC of 160 mg/100 ml was 55% and that of 280 mg/100 ml was 75%.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0340-9937
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
234-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Left ventricular hemodynamics in acute alcohol intoxication in guinea pigs].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't