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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-6-23
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pubmed:abstractText |
Exposure to a variety of stressors produces a subsequent analgesic reaction. This stress-induced analgesia (SIA) is sometimes opioid in nature (reversed by opiate antagonists and cross-tolerant with morphine) and sometimes nonopioid. Both 30 min of intermittent footshock and 60-80 five-sec tailshocks have been shown to produce opioid SIA, whereas 3 min of continuous footshock and 5-40 tailshocks produce nonopioid SIA. We report that both of the opioid SIA procedures produce a learned helplessness effect as assessed by shuttlebox escape acquisition and an analgesia that is reinstatable 24 hr. later. The nonopioid procedures produce neither a learned helplessness effect nor a reinstatable analgesia. It is argued that these data implicate the learning of uncontrollability in the activation of opioid systems.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0097-7403
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
80-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6682435-Analgesia,
pubmed-meshheading:6682435-Animals,
pubmed-meshheading:6682435-Avoidance Learning,
pubmed-meshheading:6682435-Electroshock,
pubmed-meshheading:6682435-Endorphins,
pubmed-meshheading:6682435-Escape Reaction,
pubmed-meshheading:6682435-Foot,
pubmed-meshheading:6682435-Helplessness, Learned,
pubmed-meshheading:6682435-Humans,
pubmed-meshheading:6682435-Male,
pubmed-meshheading:6682435-Narcotic Antagonists,
pubmed-meshheading:6682435-Rats,
pubmed-meshheading:6682435-Reaction Time,
pubmed-meshheading:6682435-Stress, Physiological,
pubmed-meshheading:6682435-Tail
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pubmed:year |
1983
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pubmed:articleTitle |
The opioid/nonopioid nature of stress-induced analgesia and learned helplessness.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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