Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-6-20
pubmed:abstractText
As antigen-presenting and/or monokine-secreting cells, macrophages play a major role in immunoregulation. Proteases of macrophage origin (cathepsin G, elestase, thrypsin and pronase) act on cell surfaces of different cell lines, inducing cell activation, e.g. of B-lymphocytes. T-lymphocytes might be stimulated by the activating factor LAF. Other macrophage products (CSF, FIM) control monocyte production in bone marrow. While lymphocytes are the target cell lines for classical immunosuppressive agents, mononuclear phagocytes are kept for the major cell population affected by antiinflammatory drugs. The presented study outlines the significance of the mononuclear-phagocytesystem in antiinflammatory drug research. The inhibiting potency of antiinflammatory drugs on the monocyte-macrophage cell line as an additional immunoregulatory principle should be discussed.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0340-1162
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-34
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Immunomodulation by symptomaticly active antirheumatic agents].
pubmed:publicationType
Journal Article, English Abstract