Linked Life Data

6671473

Source:http://linkedlifedata.com/resource/pubmed/id/6671473

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-5-11
pubmed:abstractText
The present study was designed to provide further evidence that high doses of systemically administered epinephrine can result in a post-ganglionic chemical sympathectomy and to look for evidence of regeneration of nerve terminals. Three days following the systemic administration of a high dose of epinephrine a prolapse of the cat nictitating membrane was observed. Examination of the inferior smooth muscle associated with the membrane revealed ultrastructural evidence of nerve terminal destruction which was associated with a marked depletion of endogenous norepinephrine as measured with a catecholamine radioenzyme assay. Three weeks following treatment, appearance of nerve terminals and endogenous norepinephrine levels in the contralateral nictitating membrane were indistinguishable from untreated controls. High doses of epinephrine appear to result in nerve terminal degeneration, followed by regeneration, similar to that reported following 6-hydroxydopamine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
447-53
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Post-ganglionic chemical sympathectomy of the cat nictitating membrane following systemic epinephrine: degeneration of nerve terminals followed by regeneration.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't