Linked Life Data

6665763

Source:http://linkedlifedata.com/resource/pubmed/id/6665763

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-3-23
pubmed:abstractText
Three different schedules of treatment with warfarin were studied in rats bearing a polyethylene cannula in their abdominal aorta. The time of occlusion of the vascular prosthesis was significantly prolonged when warfarin was started 24 hr previously, at the time of loop insertion or 24 hr later. When the drug treatment was started 24 hr before insertion of the loop, however, a high degree of toxicity was observed. The animals of this group that died of hemorrhage had significantly lower mean thrombotest levels. On the other hand, the correlation between occlusion of the loop and level of anticoagulation was not as simple as one might anticipate; on the one hand, severe anticoagulation did not protect all of the rats from loop occlusion, but, on the other hand, recovery from hypocoagulability was not always immediately followed by occlusion of the loop. In order to better elucidate the mechanism of the antithrombotic effect of warfarin, we also assessed the effect of the drug on platelet-vessel wall interaction by the template bleeding time. A close association existed between warfarin-induced hypocoagulability and prolongation of the bleeding time. These observations may constitute the experimental basis for a better understanding of the antithrombotic effect of warfarin in some arterial diseases and in myocardial infarction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0340-6245
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
821-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Protective effect of warfarin in arterial thrombosis: evidence from a vascular prosthesis model in rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't