Linked Life Data

6652104

Source:http://linkedlifedata.com/resource/pubmed/id/6652104

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-2-15
pubmed:abstractText
Peroxidized linoleic acid (13 OOH) induces lipid peroxidation, measured as malondialdehyde in erythrocyte ghosts and intact erythrocytes. This process can be inhibited by desferal, thiourea and butylated hydroxytoluene. During the lipid peroxidation process fluorescent chromolipids are formed. The synthesis of these chromolipids can be blocked by desferal. Peroxidized linoleic acid gives cross-linking of the proteins present in the membranes leading to the formation of higher molecular weight proteins. Also in the lower molecular weight region of SDS-electrophoresis a protein band is formed. The cross-linking process of the membrane protein is most effectively blocked by thiourea, to some extent by butylated hydroxytoluene and hardly at all by desferal. Addition of peroxidized linoleic acid to intact erythrocytes leads to a drop in the glutathione level (analogous to cumene hydroperoxide). In the presence of glucose the glutathione level can be restored.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
754
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
238-42
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The effect of (13 OOH) linoleic acid on human erythrocytes and on erythrocyte ghosts.
pubmed:publicationType
Journal Article