| pubmed-article:6643429 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6643429 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6643429 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:6643429 | lifeskim:mentions | umls-concept:C0065661 | lld:lifeskim |
| pubmed-article:6643429 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:6643429 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:6643429 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:6643429 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6643429 | pubmed:dateCreated | 1984-1-27 | lld:pubmed |
| pubmed-article:6643429 | pubmed:abstractText | A serum lectin specific for mannose and N-acetylglucosamine residues was isolated from human serum to near homogeneity mainly by affinity chromatography on a column of Sepharose 4B-mannan. The lectin, called mannan-binding protein, was a glycine-rich protein with an apparent molecular size of approximately 600,000 daltons, and had a subunit structure consisting of a single component with an apparent molecular weight of 31,000. Binding of the isolated lectin to 125I-labeled mannan was dependent upon the presence of Ca2+, proportional to the protein added, and a reversible and saturable process. Scatchard plot analysis of binding data indicated the presence of a binding site with a dissociation constant of 2.3 X 10(-9) M and a maximum capacity of 4.3 pmol of 125I-labeled mannan per microgram of protein (2.6 mol of mannan per mol of the protein). The mannan-binding protein, is different from C-reactive protein (CRP) and amyloid P-component (SAP), both of which are serum components known to bind polysaccharides in the presence of Ca2+. A distinct binding activity toward mannan which did not require Ca2+ was attributed to immunoglobulins (IgG). | lld:pubmed |
| pubmed-article:6643429 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6643429 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6643429 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6643429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6643429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6643429 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6643429 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6643429 | pubmed:issn | 0021-924X | lld:pubmed |
| pubmed-article:6643429 | pubmed:author | pubmed-author:KawasakiNN | lld:pubmed |
| pubmed-article:6643429 | pubmed:author | pubmed-author:YamashinaII | lld:pubmed |
| pubmed-article:6643429 | pubmed:author | pubmed-author:KawasakiTT | lld:pubmed |
| pubmed-article:6643429 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6643429 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:6643429 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6643429 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6643429 | pubmed:pagination | 937-47 | lld:pubmed |
| pubmed-article:6643429 | pubmed:dateRevised | 2007-12-19 | lld:pubmed |
| pubmed-article:6643429 | pubmed:meshHeading | pubmed-meshheading:6643429-... | lld:pubmed |
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| pubmed-article:6643429 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6643429 | pubmed:articleTitle | Isolation and characterization of a mannan-binding protein from human serum. | lld:pubmed |
| pubmed-article:6643429 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6643429 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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