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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-12-21
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pubmed:abstractText |
The mechanism by which Clostridium difficile toxin B causes cells in culture to round was investigated. Cultured human lung fibroblasts and rabbit aortic smooth muscle cells were treated with partially purified or purified toxin B and monitored by light and transmission electron microscopy (TEM). Both preparations caused progressive cell rounding which correlated with disorganization of actin-containing myofilament bundles. Thin myofilaments became fragmented and finally disappeared (after 24 h) and dense bodies became more prominent, while all other organelles appeared unaffected.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-4827
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
413-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6628564-Animals,
pubmed-meshheading:6628564-Aorta,
pubmed-meshheading:6628564-Bacterial Proteins,
pubmed-meshheading:6628564-Bacterial Toxins,
pubmed-meshheading:6628564-Cell Line,
pubmed-meshheading:6628564-Cells, Cultured,
pubmed-meshheading:6628564-Fibroblasts,
pubmed-meshheading:6628564-Humans,
pubmed-meshheading:6628564-Lung,
pubmed-meshheading:6628564-Microscopy, Electron,
pubmed-meshheading:6628564-Muscle, Smooth, Vascular,
pubmed-meshheading:6628564-Rabbits
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pubmed:year |
1983
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pubmed:articleTitle |
Ultrastructural effects of Clostridium difficile toxin B on smooth muscle cells and fibroblasts.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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