Linked Life Data

6626425

Source:http://linkedlifedata.com/resource/pubmed/id/6626425

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-12-17
pubmed:abstractText
The forearm resistance vessels of men with primary hypertension respond to verapamil with a greater than normal dilatation relative to that induced by sodium nitroprusside. We have examined the effect on this functional abnormality of treatment with chlorthalidone (50 mg daily in 16 patients) and atenolol (100 mg daily in eight patients and 200 mg daily in two). The responsiveness of the forearm resistance vessels to local intra-arterial infusion of verapamil and sodium nitroprusside was assessed before treatment and again after a minimum of 1 month of drug therapy. Forearm blood flow was measured by venous occlusion plethysmography. Chlorthalidone induced significant reductions in calculated mean arterial pressure, which fell from 135 +/- 4 to 117 +/- 4 mm Hg, and the dilator response to verapamil at 5 micrograms/min, which was reduced from 2.4 +/- 0.2 to 1.5 +/- 0.2 ml min-1 100 ml-1 forearm; the response to sodium nitroprusside at 3.2 micrograms/min was not significantly changed. Atenolol induced significant reductions in mean arterial pressure, which fell from 134 +/- 6 to 123 +/- 6 mm Hg, heart rate which fell from 72 +/- 3 to 55 +/- 2 beats/min, and response to verapamil at 5 micrograms/min which fell from 2.7 +/- 0.2 to 2.1 +/- 0.2 ml min-1 100 ml-1 forearm; the response to sodium nitroprusside was not significantly changed. Both drugs caused reversion towards normal of the relative enhancement of responsiveness to verapamil that was present before treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-13575338, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-13698661, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-13769383, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-13817927, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-28875, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-4319537, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-4623697, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-5084985, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-5458179, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-6279504, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-6292738, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-7083762, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-7218655, http://linkedlifedata.com/resource/pubmed/commentcorrection/6626425-920261
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-32
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Effect of treatment with chlorthalidone and atenolol on response to dilator agents in the forearm resistance vessels of men with primary hypertension.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't