Linked Life Data

6626050

Source:http://linkedlifedata.com/resource/pubmed/id/6626050

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-11-23
pubmed:abstractText
The plasma clearance of 125I-ovine placental lactogen (125I-oPL) in pregnant, non-pregnant and foetal sheep followed a biphasic exponential curve. The initial half-life (t1(1/2)) of the hormone ranged from 5.7-12.7 min. The molecular identity of 125I-oPL in plasma samples was examined by gel filtration chromatography. At the end of blood sampling, the high concentrations of radioactivity in the thyroid, kidney and urine were largely non-protein-bound. A similar pattern was obtained for the low concentration of radioactivity in amniotic fluid. The maternal-foetal compartments showed negligible bi-directional transfer of radioactivity. The plasma t1(1/2) of 125I-oPL determined here provides evidence that the hormone has a short biological half-life in sheep. The virtual lack of placental passage of the hormone implies discrete mechanisms for unidirectional secretion of oPL into the two circulatory systems. Our data also suggest the importance of the kidneys in the metabolism of the hormone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0004-945X
pubmed:author
pubmed:issnType
Print
pubmed:volume
61 (Pt 3)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Plasma clearance and distribution of 125I-ovine placental lactogen in sheep.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't