Linked Life Data

6617221

Source:http://linkedlifedata.com/resource/pubmed/id/6617221

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1983-11-23
pubmed:abstractText
Changes in plasma catecholamine (CA) levels and hemodynamic responses after a dopamine (DA) infusion of 20 micrograms/kg body weight per min were studied in dogs with a normal acid-base state (pH 7.4, PaCO2 40 torr) and in the same animals after induction of severe metabolic acidosis (pH 7.0, PaCO2 40 torr). DA increased plasma norepinephrine (NE) levels from .487 +/- .109 ng/ml to 3.077 +/- 0.357 ng/ml in the normal acid-base state, and from 1.762 +/- .521 ng/ml to 9.533 +/- 1.403 ng/ml in acidosis. Plasma epinephrine (E) levels in normal and acidotic states were also increased by DA infusion. In the normal acid-base state DA increased myocardial contractility and cardiac index (CI). DA also increased myocardial contractility during acidosis, but the response of CI to DA was abolished. DA significantly decreased systemic vascular resistance index (SVRI) in the normal acid-base state and significantly increased SVRI in acidosis. Acidosis appears to enhance the rate of conversion of DA to NE and E. The failure of DA to increase CI in acidosis may be a result of the increased afterload on the left ventricle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0090-3493
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
817-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Plasma catecholamine levels and hemodynamic responses of severely acidotic dogs to dopamine infusion.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't