Linked Life Data

6607584

Source:http://linkedlifedata.com/resource/pubmed/id/6607584

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-3-9
pubmed:abstractText
The experiment was performed in order to approach the question whether denatured epithelial debris in the tonsillar crypts could be an antigenic substance which might be responsible for inducing autoallergic reactions in the skin. Identical antigenicity of the tonsillar epithelium and of the skin was determined by immunofluorescence study. Then heat-denatured skin extract was used as a model system for studying the antigenicity of denatured epithelial debris. A blastoid transformation study of tonsil and peripheral blood lymphocytes obtained from patients with pustulosis palmaris et plantaris and control individuals was carried out by stimulating with heat-denatured skin extract. Tonsil lymphocytes responded well to skin extract, but peripheral blood lymphocytes scarcely responded at all. Skin extract induced transformation of tonsil lymphocytes occurred in the T-cell fraction, but not in the B-cell fraction. The results indicate that denatured tonsillar epithelium can induce an immune response of tonsil lymphocytes as autoantigen, and that the blastogenesis observed was dependent upon T cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0365-5237
pubmed:author
pubmed:issnType
Print
pubmed:volume
401
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-74
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Immunological study of pustulosis palmaris et plantaris. Blastoid transformation of tonsil and peripheral blood lymphocytes by stimulation with human skin extract.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't