Linked Life Data

6604229

Source:http://linkedlifedata.com/resource/pubmed/id/6604229

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5930
pubmed:dateCreated
1983-10-21
pubmed:abstractText
Natural killer (NK) activity is a poorly understood component of the immune system, generally identified as the ability to kill certain tumour cells. Perhaps the most controversial issue has been the lineage to which cells displaying this activity belong. Extensive studies of surface antigens on cells with NK activity in both mouse and man have led to enigmatic results, such cells apparently bearing markers of both T-cell (Thy-1 and E receptor) and myeloid (Mac-1 and OKM1) lineages. A fresh approach to this problem would be to take cells of known lineage and test whether they express, or could be induced to express, NK cell function. Using this approach we show here that monoclonal cytotoxic T lymphocyte (CTL) lines can be induced, by culture in high concentrations of spleen cell supernatant, to express a new lytic activity apparently identical with that of splenic cells NK activity. Preliminary evidence implicates both interleukin-2 (IL-2) and interferon (IFN) as mediators of this phenomenon. These findings clearly demonstrate that cells of T cell lineage have the capacity to express NK activity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
305
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Reversible induction of natural killer cell activity in cloned murine cytotoxic T lymphocytes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.