Linked Life Data

6604045

Source:http://linkedlifedata.com/resource/pubmed/id/6604045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1983-10-8
pubmed:abstractText
Factors of practical expediency influencing magnetic fixation of circulating microspheres, known to be capable of carrying therapeutically effective drugs, were studied in three different anatomic sites in rats: the tail, the hind leg, and the head (including both soft tissues and brain). Specific localization of magnetic microspheres was achieved at these three sites, but only with varying degrees of success. Specific targeting of the microspheres within brain tissue could not be accomplished. Factors influencing and tending to restrict specific retention of circulating microspheres by an external magnetic force include: complex vasculature networks, subsurface depth, and tissue-vascular barriers. Even with magnets producing high magnetic field gradients, effective localization of microspheres would appear to be restricted to tissues relatively close to body surfaces.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-2180
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
631-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Magnetic microspheres as drug carriers: factors influencing localization at different anatomical sites in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't