Linked Life Data

6603472

Source:http://linkedlifedata.com/resource/pubmed/id/6603472

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-9-9
pubmed:abstractText
The dissemination of a neurovirulent strain of influenza A/WSN (HON1) virus from infected lungs to brains of thymus-deficient nude and immunocompetent furred mice inoculated intranasally was compared. Nude mice were more susceptible to lethal disease following intranasal (i.n.) inoculation with A/WSN virus than furred mice based on the number of plaque-forming units (PFU) of virus required to constitute a median lethal dose (LD50). In normal mice, virus was cleared from the lungs of survivors and dissemination of virus from lung to brain was detected only rarely. Nude mice, in contrast, had frequent and early deaths with significant brain virus titers and histologic evidence of encephalitis. Adoptive immunization of recipient nude mice with suspensions of cytotoxic T-lymphocytes secondarily stimulated in vitro 24 h after i.n. challenge, reduced both brain virus titers and mortality in these animals. These data indicated that T-lymphocytes were a significant factor in preventing dissemination of neurotropic virus from lungs to the brains of infected mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-58
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Evidence that T-lymphocytes are part of the blood-brain barrier to virus dissemination.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.