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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-5-27
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pubmed:abstractText |
The inhibitory effect of glucocorticoids on the mitogenesis of human T cells derived from thymus and peripheral blood compartments have been investigated. The capacity of dexamethasone (Dex) (10(-7) M) of inhibiting the peripheral blood lymphocyte (PBL) mitogenesis was inversely correlated with the phytohemagglutinin (PHA) concentration used. Conversely, Dex completely (greater than 90%) inhibited the thymocyte mitogenesis, irrespective of PHA concentrations. T cells purified from PBL (M phi less than or equal to 1%) behaved as thymocytes regarding the Dex inhibitory pattern. The addition of macrophages (M phi) or interleukin 1 (IL1) was effective in removing the Dex inhibitory effect on T cells purified from PBL, but not on thymocytes. The higher corticosensitivity of thymocyte mitogenesis in comparison to PBL mitogenesis cannot be explained by differences in the relative number of M phi, but seems an intrinsic property of these less mature T cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-8749
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6600979-Cell Survival,
pubmed-meshheading:6600979-Child,
pubmed-meshheading:6600979-Child, Preschool,
pubmed-meshheading:6600979-Dexamethasone,
pubmed-meshheading:6600979-Dose-Response Relationship, Immunologic,
pubmed-meshheading:6600979-Humans,
pubmed-meshheading:6600979-Immunosuppressive Agents,
pubmed-meshheading:6600979-Interleukin-1,
pubmed-meshheading:6600979-Lymphocyte Activation,
pubmed-meshheading:6600979-Macrophages,
pubmed-meshheading:6600979-Phytohemagglutinins,
pubmed-meshheading:6600979-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Modulation of glucocorticoid inhibitory action on human lymphocyte mitogenesis: dependence on mitogen concentration and T-cell maturity.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|