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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
Peyer's patch (PP) and mesenteric lymph node (MLN) cell cultures from young adult X-linked immunodeficient (xid) CBA/N and (CBA/N X DBA/2) F1 male mice support primary anti-sheep erythrocyte (SRBC) plaque-forming cell (PFC) responses, which suggests that gut-associated lymphoreticular tissue (GALT) contains a normal B lymphocyte subpopulation. Further support for this was provided by the observation that PP cells from xid mice gave responses to both TI-1 and TI-2 antigens that were similar to the responses of PP cell cultures from normal mice. Spleen cell cultures from xid mice were unresponsive to SRBC and TI-2 antigens. Proof that GALT of xid mice contain mature B lymphocytes was provided by the demonstration of PP B cells that bear a low density of surface immunoglobulin M. When these cells were separated by flow cytometry and immunized with trinitrophenyl (TNP)-Ficoll in vitro, good anti-TNP PFC responses were observed. These results suggest that GALT of young adult xid mice contain mature B cells and may represent the origin for the mature B cell responses seen in aged xid mice.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-1079035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-1080788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-14029139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-448116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-5653817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-6153089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-6159444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-6168685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-6972986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-6979042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-6997384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-7044950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-789772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-805203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6600493-99320
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
789-94
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6600493-Aging,
pubmed-meshheading:6600493-Animals,
pubmed-meshheading:6600493-B-Lymphocytes,
pubmed-meshheading:6600493-Cells, Cultured,
pubmed-meshheading:6600493-Female,
pubmed-meshheading:6600493-Immunoglobulin M,
pubmed-meshheading:6600493-Lymph Nodes,
pubmed-meshheading:6600493-Lymphocyte Activation,
pubmed-meshheading:6600493-Lymphoid Tissue,
pubmed-meshheading:6600493-Male,
pubmed-meshheading:6600493-Mice,
pubmed-meshheading:6600493-Mice, Inbred CBA,
pubmed-meshheading:6600493-Mice, Inbred DBA,
pubmed-meshheading:6600493-Peyer's Patches,
pubmed-meshheading:6600493-Trinitrobenzenes
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pubmed:year |
1983
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pubmed:articleTitle |
Evidence for a mature B cell subpopulation in Peyer's patches of young adult xid mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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