Linked Life Data

6596283

Source:http://linkedlifedata.com/resource/pubmed/id/6596283

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-3-5
pubmed:abstractText
The metabolism of prostaglandin F2 alpha (PGF2 alpha) was investigated in the fetal cotyledons of human term placentas by an in vitro perfusion technique. When 80 nmol of 14C-PGF2 alpha was infused in 2 min into the chorionic artery, 56 +/- 7% (mean +/- SEM, n = 7) of the infused radioactivity appeared in the nonrecirculating venous effluent in 6 min. Most of this radioactivity was as unmetabolized PGF2 alpha. Only 12 +/- 2% of the radioactivity in this venous effluent was as metabolites, the major metabolite being 13,14-dihydro-15-keto-PGF2 alpha. During the following 2 min, 2 +/- 1% of the infused radioactivity appeared in the venous effluent. The fluid trickling through the decidual plate contained 5 +/- 1% of the infused radioactivity. After the perfusion 10-15% of the infused radioactivity was retained in the tissue, being mainly as 13,14-dihydro-15-keto-PGF2 alpha. The oxygen consumption of the tissue was 0.4 +/- 0.1 ml/100 g/min, which is adequate for vital placenta tissue. The study suggests that the metabolism of PGF2 alpha is negligible in the fetal circulation of the human term placenta.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-7346
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
306-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Metabolism of prostaglandin F2 alpha in the fetal circulation of the human term placenta in vitro.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't