Linked Life Data

6595439

Source:http://linkedlifedata.com/resource/pubmed/id/6595439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-2-6
pubmed:abstractText
For evaluation of the promotional effects of dietary trans-fatty acids on large intestinal carcinogenesis, 120 inbred female F344 rats were divided into 6 groups and fed a 25% elaidic acid diet, a 25% oleic acid diet, or a regular (4.5% fat) chow diet. Ninety animals, 30 per dietary group, received weekly im injections of azoxymethane (2 mg/kg; CAS: 25843-45-2). None of the 30 saline-injected control animals, 10 per dietary group, fed any of the three diets developed tumors. There were twice as many animals with adenocarcinoma of the large intestine from the trans-fatty acid diet group as compared with either the cis-fatty acid diet group or regular diet groups. Chi-square analysis showed that the difference between the incidence of large intestinal carcinomas was not significant between the cis- and trans-fatty acid diets. The difference between the regular diet and trans-fatty acid diet groups was not significant at the 5% level (P = .08). A higher, but nonstatistically significant, incidence of nephroblastomas and squamous ear duct neoplasms was also observed in carcinogen-treated animals maintained on each of the high-fat diets as compared with the incidence of both in treated animals fed the regular chow diet.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1293-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Large intestinal carcinogenesis. I. Promotional effect of dietary fatty acid isomers in the rat model.
pubmed:publicationType
Journal Article, Comparative Study