Linked Life Data

6587160

Source:http://linkedlifedata.com/resource/pubmed/id/6587160

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-7-20
pubmed:abstractText
The relationship between operative procedures and the incidence of remnant stomach carcinoma was investigated in male Wistar rats orally treated with N-methyl-N'-nitro-N-nitrosoguanidine [(MNNG) CAS: 70-25-7; 1-methyl-3-nitro-1-nitrosoguanidine]. A total of 178 rats was divided into 5 groups: After gastrectomy in which half of the glandular stomach was removed, group 1 received Billroth II reconstruction; group 2 was given short Roux-en-Y reconstruction; group 3 had long Roux-en-Y reconstruction; group 4 received gastrotomy alone; and group 5 consisted of nonoperated control rats. The incidence of gastric adenocarcinoma in MNNG-treated rats was significantly higher in group 1 (38.9%) as compared with that in group 3 (7.1%) and that in group 5 (9.5%). All tumors developed in the gastroenteric anastomotic area. Histologic examination of the gastric mucosa revealed atrophic gastritis and erosion in the gastroenteric anastomotic area, especially in rats with carcinoma. These findings seem to implicate the duodenogastric reflux, especially the reflux of bile acids, in the development of remnant stomach carcinoma in rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1431-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Possible role of duodenogastric reflux on the development of remnant gastric carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
pubmed:publicationType
Journal Article, Comparative Study