|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
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|
pubmed:dateCreated |
1984-5-30
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|
pubmed:abstractText |
A phase I study of a new anthracycline, 4'-epiadriamycin was conducted in a total of 28 patients with various advanced cancers refractory to standard chemotherapies and 26 were evaluable. A dose limiting factor was leukopenia reaching a nadir approximately 2 weeks later and about one week needed for the recovery. Thrombocytopenia was milder and less frequent than leukopenia but dose-related. Nausea and alopecia were observed in the majority of patients but vomiting was relatively rare and therefore non-hematologic toxicities were judged to be milder than adriamycin. A recommended dose for patients having prior extensive chemotherapies was determined to be 60 mg/m2 in 3 weeks intervals.
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pubmed:language |
jpn
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
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pubmed:issn |
0385-0684
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
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pubmed:pagination |
926-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6586111-Adult,
pubmed-meshheading:6586111-Aged,
pubmed-meshheading:6586111-Alopecia,
pubmed-meshheading:6586111-Antibiotics, Antineoplastic,
pubmed-meshheading:6586111-Breast Neoplasms,
pubmed-meshheading:6586111-Doxorubicin,
pubmed-meshheading:6586111-Drug Evaluation,
pubmed-meshheading:6586111-Epirubicin,
pubmed-meshheading:6586111-Female,
pubmed-meshheading:6586111-Humans,
pubmed-meshheading:6586111-Leukopenia,
pubmed-meshheading:6586111-Lung Neoplasms,
pubmed-meshheading:6586111-Male,
pubmed-meshheading:6586111-Middle Aged,
pubmed-meshheading:6586111-Neoplasms,
pubmed-meshheading:6586111-Ovarian Neoplasms,
pubmed-meshheading:6586111-Stomach Neoplasms,
pubmed-meshheading:6586111-Thrombocytopenia
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|
pubmed:year |
1984
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|
pubmed:articleTitle |
[A phase I trial of 4'-epiadriamycin].
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|
pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|
