Linked Life Data

6584056

Source:http://linkedlifedata.com/resource/pubmed/id/6584056

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-4-6
pubmed:abstractText
Alveolar macrophages isolated by bronchoalveolar lavage from nonsmoking patients with sarcoidosis, interstitial pulmonary fibrosis (DIF), and normal volunteers were examined for surface expression of Ia-like (DR) antigen using a monoclonal antibody technique. We found increased percentages of alveolar macrophages expressing DR antigen in the 8 patients with sarcoidosis (77 +/- 3%) and the 7 patients with DIF (78 +/- 3%) over that in the 9 healthy, nonsmoking volunteers (21 +/- 5%, p less than 0.05). Four patients, 2 with DIF and 2 with sarcoidosis, were studied before and 3 months after initiation of therapy. A decrease in DR antigen expression was found to be associated with clinical improvement. Alveolar macrophages from 3 patients were studied serially in culture, with a steady decrease in DR antigen expression with time. We conclude (1) that alveolar macrophages from patients with sarcoidosis and DIF are in a state of heightened activity, and (2) that DR antigen expression may be an indicator of disease activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-24
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Expression of Ia-like (DR) antigen on human alveolar macrophages isolated by bronchoalveolar lavage.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't