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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1984-4-12
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pubmed:abstractText |
Proliferation of confluent kidney epithelial cell cultures (BSC-1 line) is inhibited by a protein (Mr approximately equal to 24,000) that is secreted by the cells. The mechanism of action of this growth inhibitor was sought by studying its effect on net Na+ flux because increased availability of Na+ in the culture medium had been shown to stimulate cell growth. The increase in cell Na+ content observed during stimulation of the growth after a medium change was attenuated in the presence of the purified inhibitor. Inhibition of both cell Na+ accumulation and growth in the presence of the protein was reversed completely by addition of NaCl to the medium. These results suggest that control of net Na+ flux and growth in kidney epithelial cells could be mediated, at least in part, by a secreted cellular protein.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-1060129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-13707364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-270701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-272650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-273914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-303774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-4590237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-4808440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-509519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-56781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6105618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6253813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6261956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6266401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6287515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6604275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6638165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6839367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6935677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6969400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-6979542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-730779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-7370987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-807913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-82969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6583679-8729
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
793-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6583679-Animals,
pubmed-meshheading:6583679-Biological Transport, Active,
pubmed-meshheading:6583679-Cell Division,
pubmed-meshheading:6583679-Cell Line,
pubmed-meshheading:6583679-Cells, Cultured,
pubmed-meshheading:6583679-Cercopithecus aethiops,
pubmed-meshheading:6583679-Epithelium,
pubmed-meshheading:6583679-Kidney,
pubmed-meshheading:6583679-Kinetics,
pubmed-meshheading:6583679-Proteins,
pubmed-meshheading:6583679-Sodium
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pubmed:year |
1984
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pubmed:articleTitle |
Cell growth and net Na+ flux are inhibited by a protein produced by kidney epithelial cells in culture.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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