| pubmed-article:6574463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6574463 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:6574463 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:6574463 | lifeskim:mentions | umls-concept:C0806036 | lld:lifeskim |
| pubmed-article:6574463 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:6574463 | lifeskim:mentions | umls-concept:C0700364 | lld:lifeskim |
| pubmed-article:6574463 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:6574463 | lifeskim:mentions | umls-concept:C1151664 | lld:lifeskim |
| pubmed-article:6574463 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:6574463 | pubmed:dateCreated | 1983-7-8 | lld:pubmed |
| pubmed-article:6574463 | pubmed:abstractText | Rats fed a K-deficient diet exhibit accelerated kidney growth and enhanced activity of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (G3PD; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase, EC 1.2.1.12). Cultures of renal epithelial cells (BSC-1 line) served as a model for this phenomenon because a reduction in the medium K concentration from 5.4 to 3.2 mM resulted in augmented growth and increased G3PD activity. Mixing the soluble supernatant fraction from cells grown in low-K medium (3.2 mM) with that from cells grown in control medium indicated that the cytosol of low-K cells contained a positive modifier of G3PD activity. Appearance of modifier activity that occurred within 1 hr after exposure of cells to low-K medium was blocked by cycloheximide but not by actinomycin D. Modifier activity was also observed in mouse fibroblasts stimulated by low-K medium and in proliferating renal medullary tissue from rats fed a K-deficient diet. A single protein that contained G3PD-stimulating activity was isolated from the soluble supernatant of BSC-1 cells exposed to low-K medium. This protein was not detectable in control cells. The material yielded a single band on NaDodSO4/polyacrylamide gel electrophoresis with an apparent Mr of 62,000. These results suggest that a new protein with the capacity to stimulate G3PD activity appears in the cytosol during the initiation of cell growth. | lld:pubmed |
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| pubmed-article:6574463 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6574463 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6574463 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6574463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6574463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6574463 | pubmed:month | May | lld:pubmed |
| pubmed-article:6574463 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6574463 | pubmed:author | pubmed-author:AithalH NHN | lld:pubmed |
| pubmed-article:6574463 | pubmed:author | pubmed-author:TobackF GFG | lld:pubmed |
| pubmed-article:6574463 | pubmed:author | pubmed-author:Walsh-ReitzM... | lld:pubmed |
| pubmed-article:6574463 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6574463 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:6574463 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6574463 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6574463 | pubmed:pagination | 2941-5 | lld:pubmed |
| pubmed-article:6574463 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:6574463 | pubmed:meshHeading | pubmed-meshheading:6574463-... | lld:pubmed |
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| pubmed-article:6574463 | pubmed:meshHeading | pubmed-meshheading:6574463-... | lld:pubmed |
| pubmed-article:6574463 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6574463 | pubmed:articleTitle | Appearance of a cytosolic protein that stimulates glyceraldehyde-3-phosphate dehydrogenase activity during initiation of renal epithelial cell growth. | lld:pubmed |
| pubmed-article:6574463 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6574463 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6574463 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6574463 | lld:pubmed |
