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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1984-9-12
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pubmed:abstractText |
A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to the COOH-terminal sequence of neurotensin. This structure has been confirmed by synthesis. Neuromedin N exhibits a contractile activity on guinea pig ileum and induces a hypotensive response in the rat similar to that with neurotensin. These findings suggest that neuromedin N may be a new neuromediator or hormone with a specific spectrum of biological activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
|
pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
31
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
542-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6547840-Amino Acid Sequence,
pubmed-meshheading:6547840-Animals,
pubmed-meshheading:6547840-Biological Assay,
pubmed-meshheading:6547840-Blood Pressure,
pubmed-meshheading:6547840-Chromatography, High Pressure Liquid,
pubmed-meshheading:6547840-Guinea Pigs,
pubmed-meshheading:6547840-Ileum,
pubmed-meshheading:6547840-Muscle Contraction,
pubmed-meshheading:6547840-Neurotensin,
pubmed-meshheading:6547840-Peptide Fragments,
pubmed-meshheading:6547840-Rats,
pubmed-meshheading:6547840-Spinal Cord,
pubmed-meshheading:6547840-Structure-Activity Relationship,
pubmed-meshheading:6547840-Swine
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pubmed:year |
1984
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pubmed:articleTitle |
Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|