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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1985-10-7
|
| pubmed:abstractText |
Because cytochalasin D affects intercellular junctions the effect of this agent on peritoneal transport was investigated in normal rabbits. Using commercially available dialysis solution, short-term control peritoneal dialyses were compared in the same animals to dialyses in which cytochalasin D was added intraperitoneally. A dose (325-920 micrograms/kg) dependent increase in peritoneal clearances of urea (49% increment at high dose) and of creatinine (67% increment) occurred when cytochalasin D was added. When solute transport was highest at the maximal dose, osmotically induced ultrafiltration decreased significantly to 33% of control values. Cytochalasin D induces aberrations in solute transport that resemble those accompanying and occasionally following peritonitis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0740-1353
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
85-8
|
| pubmed:dateRevised |
2006-7-19
|
| pubmed:meshHeading |
pubmed-meshheading:6537689-Animals,
pubmed-meshheading:6537689-Biological Transport,
pubmed-meshheading:6537689-Creatinine,
pubmed-meshheading:6537689-Cytochalasin D,
pubmed-meshheading:6537689-Cytochalasins,
pubmed-meshheading:6537689-Dose-Response Relationship, Drug,
pubmed-meshheading:6537689-Peritoneal Dialysis,
pubmed-meshheading:6537689-Rabbits,
pubmed-meshheading:6537689-Urea,
pubmed-meshheading:6537689-Water-Electrolyte Balance
|
| pubmed:articleTitle |
Acceleration of peritoneal solute transport by cytochalasin D.
|
| pubmed:publicationType |
Journal Article
|