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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1985-4-29
|
| pubmed:abstractText |
In 8 normal volunteers, the minimal phototoxic dose was determined at 15 min intervals up to 60 min and thereafter every 30 min up to 4 h; 8-methoxypsoralen (8-MOP) was administered as a solution and small additional doses were given during the course of the experiment, so that a more or less predictable and stable plasma concentration was obtained and maintained for about 2 h. Three of the subjects absorbed 8-MOP very rapidly, already reaching plasma concentrations above 200 ng/ml after 15 min; in the other 5, absorption was slower and comparable levels were achieved only after 30 to 90 min. In the fastest absorbers, there was a 15 to 30 min lag between reaching a high plasma level and a low MPD. In the other cases, such a delay was not seen. This suggests that the time to reach peak concentration in the skin is not influenced by changes in absorption rate: simulations based on the classical plasma concentration equations for a two-compartmental model also show this. Afterwards, the skin sensitivity decreased in most cases parallel to the plasma concentrations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0108-9684
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
79-84
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1984
|
| pubmed:articleTitle |
8-Methoxypsoralen plasma levels and phototoxic effect.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|