Linked Life Data

6526229

Source:http://linkedlifedata.com/resource/pubmed/id/6526229

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1985-4-10
pubmed:abstractText
The aim of this study was to compare the stimulation of the external pancreatic secretion induced in rats by two glucose analogs: 5-thio-glucose (5-TG) and 2-deoxy-glucose (2-DG). In rats with an acute pancreatic fistula, 5-TG and 2-DG induced a dose-related increase in outputs of sodium (reflecting the volume), bicarbonate and total protein of the pancreatic juice. The efficacy of both drugs was not significantly different. Maximal responses were obtained with 75 mg/kg 5-TG and 225 mg/kg 2-DG and were approximately 3.5 x (sodium), 5 x (bicarbonate) and 8.5 x (protein) the basal level. Dose-response curves to 5-TG were shifted to the left with respect to 2-DG. The DE50 was approximately 25 mg/kg for 5-TG and 60 mg/kg for 2-DG. The molar potency ratio was 2.5 x, 3.1 x and 3.3 x in favor of 5-TG, for sodium, bicarbonate and protein respectively. The potency, but not the efficacy, of 5-TG is thus greater than that of 2-DG in stimulating external pancreatic secretion.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0399-8320
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
746-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
[Effect of 5-thioglucose on external pancreatic secretion in rats. Comparison with 2-deoxyglucose].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract