Linked Life Data

6517052

Source:http://linkedlifedata.com/resource/pubmed/id/6517052

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-2-4
pubmed:abstractText
Segregation analysis, employing nuclear families, is the most frequently used method to evaluate the mode of inheritance of a trait. To our knowledge, there exists no tabular information regarding the sample sizes required of individuals and families needed to perform a significance test of a specific segregation ratio for a predetermined power and significance level. To fill this gap, we have developed sample-size tables based on the asymptotic variance of the maximum likelihood estimate of the segregation ratio and on the normal approximation for two-sided hypothesis testing. Assuming homogeneous sibship size, minimum sample sizes were determined for testing the null hypothesis for the segregation ratio of 1/4 or 1/2 vs. alternative values of .05-.80, for the significance level of .05 and power of .8, for ascertainment probabilities of nearly 0 to 1.0, and sibship sizes 2-7. The results of these calculations indicate a complex interaction of the null and the alternate hypotheses, ascertainment probability, and sibship size in determining the sample size required for simple segregation analysis. The accompanying tables should aid in the appropriate design and cost assessment of future genetic epidemiologic studies.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1279-97
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Sample-size calculations in segregation analysis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't