Linked Life Data

6505383

Source:http://linkedlifedata.com/resource/pubmed/id/6505383

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-1-15
pubmed:abstractText
Administration of monochlorobenzene (MCB), p-dichlorobenzene (DCB), or 1,2,4-trichlorobenzene (TCB) at single doses of 800 mg/kg produced an increase in the total porphyrin content of liver of day-old chicks. Porphyrinogenic activity was higher in DCB- and TCB-treated chicks than in MCB-treated chicks. Administration of any of these compounds to chick embryos (40 mg/egg) failed to produce an induction of liver porphyrins. TCB enhanced the excretion of porphyrin in bile of chicks but not of chick embryos. In day-old chicks TCB increased hepatic cytochrome P-450 levels and the activity of 7-ethoxyresorufin deethylase. However, 7-ethoxycoumarin deethylase activity was decreased while cytosolic glutathione S-transferase activity was unchanged. These results point out the differential response of chick embryos and day-old chicks to chlorobenzene-induced changes in porphyrin metabolism as well as the differential induction of microsomal monooxygenases in chicks by TCB.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-24
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effects of chlorobenzenes on hepatic porphyrin and drug metabolism in chick embryo and day-old chick.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.