| pubmed-article:6493631 | pubmed:abstractText | The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10(-6) M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10(-5), 5 X 10(-5) and 10(-4) M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug. | lld:pubmed |
