Linked Life Data

6493583

Source:http://linkedlifedata.com/resource/pubmed/id/6493583

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1984-11-26
pubmed:abstractText
Acetylcholinesterase (AChE) inhibitor treatments were used to study the temporal course of intra- versus extracellular 16S AChE recovery in endplate regions of adult rat anterior gracilis muscles previously exposed to a brief, in situ application of diisopropylfluorophosphate (DFP). Following such enzymatic inactivation (95-100%), extracellular 16S AChE recovery began significantly later than that of intracellular (onset at approximately 36 and 12 h, respectively) but, once begun, progressed at approximately the same rate (1.32%/h). The recovery of AChE molecular form activities subsequent to identical DFP-inactivation was blocked to a large extent (65-85%) by in vivo treatment with cycloheximide, a protein synthesis inhibitor. These results support the hypothesis that extracellular 16S AChE at mammalian skeletal muscle motor endplates is primarily derived from complete, previously assembled 16S molecules originating in myofibers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Intra- versus extracellular recovery of 16S acetylcholinesterase following organophosphate inactivation in the rat.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't