Linked Life Data

6481400

Source:http://linkedlifedata.com/resource/pubmed/id/6481400

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-11-5
pubmed:abstractText
The immunogenicity of four transplantable leukemias was evaluated in syngeneic Sewall-Wright strain 2 guinea pigs. The L76 and KSL leukemias are considered appropriate models for the assessment of immunogenicity because of their recent origin and unknown (natural) etiology. The chemically induced K77 leukemia of recent origin and the long-passaged L2C leukemia of unknown etiology could be classified as experimental tumors prone to artifactual immunogenicity. Our studies clearly show that naturally occurring guinea pig leukemias are potentially immunogenic, although to a lesser degree than experimental leukemias. These findings are in contrast to previous studies in mouse and rat tumor models, which showed that naturally occurring tumors were essentially nonimmunogenic, thereby raising questions about the relevance of animal tumor models to human cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0732-6580
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-65
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
More on the relevance of animal tumor models: immunogenicity of transplantable leukemias of recent origin in syngeneic strain 2 guinea pigs.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't