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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0002092,
umls-concept:C0004827,
umls-concept:C0011615,
umls-concept:C0020517,
umls-concept:C0020960,
umls-concept:C0030705,
umls-concept:C0205276,
umls-concept:C0205421,
umls-concept:C0221912,
umls-concept:C0332256,
umls-concept:C0348011,
umls-concept:C0598322,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1705822,
umls-concept:C1706817,
umls-concept:C2754973,
umls-concept:C2911692
|
| pubmed:issue |
4
|
| pubmed:dateCreated |
1984-11-9
|
| pubmed:abstractText |
Inhalant allergens applied to the skin of sensitive atopic dermatitis patients by means of a modified patch test technique, induce acute eczematous lesions. These lesions contain basophils, eosinophils, mononuclear cells, and neutrophils and represent an example of human cutaneous basophil hypersensitivity. The role of IgE antibody in this eczematous reaction was studied by systemic and local passive transfer experiments. Plasma with high IgE antibody when infused into patients with hypogammaglobulinemia as part of their replacement treatment resulted, post infusion, in cutaneous mast cell and blood basophil sensitization as measured by quantitative skin testing and leukocyte histamine release. Subsequent patch tests on these patients using the house dust mite antigen, antigen P1, produced macroscopic erythematous responses containing mononuclear cells, and eosinophils but not basophils. Local transfer of atopic dermatitis serum with high IgE antibody produced weak macroscopic responses and in these lesions mononuclear cells and both basophils and eosinophils were present. The serum activity which allowed transfer of basophil and eosinophil recruitment was heat labile. Specifically purified antibody to the mite antigen P1 (containing IgE and IgG antibody), when transferred, allowed eosinophil but not basophil recruitment to patch test sites. These results suggest that while the allergen-induced patch test response may involve IgE antibodies, as well as the cells normally involved in delayed responses, another serum activity is also involved.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-202X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
290-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6481180-Adolescent,
pubmed-meshheading:6481180-Adult,
pubmed-meshheading:6481180-Agammaglobulinemia,
pubmed-meshheading:6481180-Allergens,
pubmed-meshheading:6481180-Basophils,
pubmed-meshheading:6481180-Dermatitis, Atopic,
pubmed-meshheading:6481180-Eosinophils,
pubmed-meshheading:6481180-Humans,
pubmed-meshheading:6481180-Hypersensitivity, Delayed,
pubmed-meshheading:6481180-Immune Sera,
pubmed-meshheading:6481180-Immunization, Passive,
pubmed-meshheading:6481180-Immunoglobulin E,
pubmed-meshheading:6481180-Middle Aged,
pubmed-meshheading:6481180-Monocytes,
pubmed-meshheading:6481180-Skin,
pubmed-meshheading:6481180-Skin Tests
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Cutaneous basophil hypersensitivity to inhalant allergens in atopic dermatitis patients: elicitation of delayed responses containing basophils following local transfer of immune serum but not IgE antibody.
|
| pubmed:publicationType |
Journal Article
|