Linked Life Data

6475496

Source:http://linkedlifedata.com/resource/pubmed/id/6475496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-10-25
pubmed:abstractText
The involvement of GABA-transaminase (GABA-T) in the blood-brain barrier to GABA was investigated using a sensitive radiotracer technique which allows measurement of tracer permeation as a cerebrovascular permeability-area product, PA. In Sprague-Dawley rats subjected to peripheral GABA-T inhibition and occlusion of hepatic circulation, chromatographic (TLC) analysis together with lyophylized plasma samples showed the radioactivity measured in brain parenchyma was derived from the permeation of unchanged [3H]GABA and not its blood-borne metabolites. Permeation (PA) of i.v. injected [3H]GABA was poor in all brain regions examined. Pretreatment of these rats with various compounds known to inhibit endothelial GABA-T activity did not cause any increased permeation of [3H]GABA into the brain. These results suggest that the poor permeation of GABA into the rat brain is unrelated to the activity of GABA-T at endothelial sites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6322
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-7
pubmed:dateRevised
2007-11-9
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The involvement of GABA-transaminase in the blood-brain barrier to radiolabelled GABA.
pubmed:publicationType
Journal Article