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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1984-10-12
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pubmed:abstractText |
L-alanosine is an antitumor compound which has recently entered clinical trials. Single i.p. doses of this drug inhibit antibody production to thymus-dependent and thymus-independent antigens as well as delayed hypersensitivity to SRBC in mice. Moreover, the in vitro lymphoproliferative responses of splenocytes to Concanavalin A and bacterial Lipopolysaccharides are also affected when the drug is added upon setting up the cultures. On the other hand, in vivo treatment with L-alanosine does not impair spleen natural killer (NK) activity. The results are discussed in an effort to characterize the immuno-suppressive activity of L-alanosine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0163-0571
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-41
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6470495-Alanine,
pubmed-meshheading:6470495-Animals,
pubmed-meshheading:6470495-Antibiotics, Antineoplastic,
pubmed-meshheading:6470495-Antibody Formation,
pubmed-meshheading:6470495-Cells, Cultured,
pubmed-meshheading:6470495-Cytotoxicity, Immunologic,
pubmed-meshheading:6470495-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:6470495-Erythrocytes,
pubmed-meshheading:6470495-Female,
pubmed-meshheading:6470495-Hypersensitivity, Delayed,
pubmed-meshheading:6470495-Killer Cells, Natural,
pubmed-meshheading:6470495-Lymphocyte Activation,
pubmed-meshheading:6470495-Male,
pubmed-meshheading:6470495-Mice,
pubmed-meshheading:6470495-Mice, Inbred C57BL,
pubmed-meshheading:6470495-Mitogens,
pubmed-meshheading:6470495-Neoplasms, Experimental,
pubmed-meshheading:6470495-Sheep,
pubmed-meshheading:6470495-Spleen
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pubmed:year |
1984
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pubmed:articleTitle |
Effect of L-alanosine on immune response.
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pubmed:publicationType |
Journal Article
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