Linked Life Data

6463591

Source:http://linkedlifedata.com/resource/pubmed/id/6463591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-8-27
pubmed:abstractText
Spleens from newborn mice less than 6-7 days of age are known to contain naturally occurring suppressor cells, which can suppress the immune reactivity of third-party adult cells. In the present study newborn spleen cell populations are shown to possess the potential to inhibit lethal graft-versus-host (GVH) disease in sublethally gamma-irradiated hosts injected with allogeneic adult cells. However, this capacity to suppress GVH disease is controlled by at least two genetic restrictions: (1) the newborn spleen cells and the adult donor cells must be histocompatible at an H-2-linked region apparently telomeric of H-2DL, and (2) the newborn spleen cells must express a strongly stimulating non-H-2 (perhaps M1s) alloantigenic phenotype. Host animals that survive GVH remain chimeric for at least 3-4 weeks but return to the host phenotype by 8-10 weeks. Thus, it appears that in sublethally irradiated hosts the newborn cells suppress donor cell reactivity long enough for the host system to recover from the effects of irradiation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Naturally occurring spleen-associated suppressor activity of the newborn mouse. Requirement for two genetic restrictions in suppression of lethal graft-versus-host disease by newborn spleen cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.