Linked Life Data

6462245

Source:http://linkedlifedata.com/resource/pubmed/id/6462245

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5978
pubmed:dateCreated
1984-9-17
pubmed:abstractText
Development and fertility in the mouse are known to be influenced by loci mapped to the T/t complex of chromosome 17. Recent evidence suggests that one or more genes near this region may also be associated with sex determination. Washburn and Eicher recently reported partial to complete sex reversal with the Thp deletion on some genetic backgrounds and suggest that this result may be due to a primary sex-determining locus (Tas) that is closely linked to, or a part of, the T locus. Sex-specific, Bkm (banded Krait minor satellite DNA)-related sequences are known to have autosomal as well as heterogametic sex chromosomal copies, but specific regions of autosomal localization have not been described. We now demonstrate the presence of chromosome Y-related DNA sequences on proximal chromosome 17 in Sex-reversed (Sxr) and normal mice using in situ hybridization of mitotic chromosomes with 3H-labelled pCS316 (ref. 4), a probe that shows major hybridization to the proximal portion of the mouse chromosome Y. These data, and those of Washburn and Eicher, argue for a gene(s) related to sex determination or differentiation within the proximal portion of mouse chromosome 17.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
310
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
579-81
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:articleTitle
Regional localization of sex-specific Bkm-related sequences on proximal chromosome 17 of mice.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.